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Brunetti IL: curcumin improves the effect of a reduced insulin dose on glycemic control and OS in streptozotocin-diabetic rats

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Altogether, these studies suggest that both melatonin and treatments aimed to remodulate circadian homeostasis hold promise not only in enhancing treatment efficacy and quality of life, but also in potentially counteracting immunosuppressive and pro-metastatic mechanisms driven by circadian disruption in BC patients